"Dream, Dream, Dream! Conduct these dreams into thoughts, and then transform them into action."
- Dr. A. P. J. Abdul Kalam
30 Aug 2023
In a groundbreaking discovery, scientists have achieved a significant breakthrough in the field of nanotechnology by successfully regrowing retina cells to address macular degeneration, the leading cause of blindness in developed countries. This revolutionary treatment utilizes synthetic, tissue-like materials on which the human cells can be regenerated, surpassing the limitations of previous methods.
Macular degeneration, characterized by the loss of cells in the retina, has been a growing concern worldwide, contributing to the rising prevalence of blindness. While humans lack the inherent ability to regrow retinal pigment cells, researchers have now found a way to accomplish this feat in laboratory settings using pluripotent stem cells.
A team of biomedical scientists at Nottingham Trent University in the UK, led by Biola Egbowon, developed 3D scaffolds composed of polymer nanofibers coated with an anti-inflammatory steroid. These scaffolds were created using an innovative technique called "electrospinning," where polyacrylonitrile and Jeffamine polymers were transformed into solid structures resembling tiny fibers, capable of attracting water and maintaining mechanical strength.
The unique combination of materials and the electrospinning process allowed the retinal pigment cells to remain viable for an impressive 150 days outside the human body, while exhibiting critical biomarkers necessary for the maintenance of retinal physiological characteristics.
Although this breakthrough holds immense promise for regenerative medicine, the researchers emphasize the need for further investigation to ensure biocompatibility with human tissue, particularly in terms of cell orientation and blood supply.